Recent progress of amino acid transporters as a novel antitumor target

Abstract Glutamine transporters transport different amino acids for cell growth and metabolism. In tumor cells, glutamine are often highly expressed play a crucial role in their growth. By inhibiting the acid of these transporters, cancer cells can be inhibited. recent years, more attention has been paid to study transporter. this article, differences between ASC system transporter 2 (ASCT2), L-type 1 (LAT1), cystine–glutamate exchange (xCT) research progress on mechanism action corresponding small molecule inhibitors summarized. This article introduces 62 related ASCT2, LAT1, xCT. These novel chemical structures provide ideas design targeted as well important references clues new anti-tumor drugs.